Anora Genetic Testing of Fetal Tissue to Determine the Genetic Cause of Pregnancy Loss and Recurrent Miscarriage

The results may help explain why the miscarriage occurred and whether you may have an increased risk of a chromosomal abnormality in a future pregnancy.

For many patients, this information can help ease the emotional burden and inform future reproductive decisions.

The Anora miscarriage test can detect:

• Whole-chromosome aneuploidy, triploidy, and tetraploidy
• Deletions and duplications > 5 Mb and down to 1 Mb when clinically significant
• Uniparental disomy

Benefits of the Anora miscarriage test:

• Anora is the only miscarriage test that uses Natera’s Parental Support bioinformatics technology, which determines the parental origin of chromosomal abnormalities, as paternal origin may indicate the need for medical care and treatment of the mother following pregnancy loss.
• Detects partial and complete molar pregnancies that require medical follow-up. A molar pregnancy can pose serious risks to the mother, including a type of cancer known as gestational trophoblastic disease (GTD). Identifying a molar pregnancy is critical for appropriate clinical management. Complete paternal uniparental disomy (UPD)* and triploidy of paternal origin are associated with a risk of molar pregnancy.
• Anora is the only miscarriage test that determines the parental origin of triploidy. This capability is important because triploidy of maternal origin does not cause a molar pregnancy and does not place the woman at risk of GTD.
• Anora can distinguish between maternal and fetal DNA, allowing maternal cell contamination to be excluded.
• Anora can determine whether a chromosomal abnormality originated in the egg or sperm.

*Complete paternal UPD means that all chromosomes are inherited exclusively from the father, which can lead to serious complications, including molar pregnancy (abnormal proliferation of trophoblastic tissue in the uterus).

Note:

1) Tissue samples must be stored in physiological saline (0.9% NaCl).

2) Tissue samples preserved or placed in formalin are not suitable for testing.

3) Parental samples are not required for testing but ARE REQUIRED to exclude maternal cell contamination in a chromosomally normal female fetus and to determine the parental origin of an abnormality.

Required biological material:

Testing is performed using tissue remaining after pregnancy loss and maternal blood.

• First-trimester pregnancy loss: chorionic villi, products of conception
• Second-trimester pregnancy loss or stillbirth: any fetal tissue (liver, skin, diaphragm, lung), umbilical cord tissue, umbilical cord blood, maternal or paternal blood