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Panorama Non-Invasive Prenatal Test for Detecting Common Fetal Chromosomal Abnormalities
Turnaround time14 календарных дней
What is the PANORAMA TEST?
It is a genetic non-invasive prenatal screening test performed using a pregnant woman’s blood that detects common trisomies, aneuploidies, and microdeletions, determines the fetal Rh factor when the mother is Rh-negative, and also includes determination of individual zygosity and fetal fraction in dizygotic twin pregnancies.
How Panorama™ differs from other existing non-invasive prenatal tests
- Detects deletions as small as 0.5 Mb
- Provides highly sensitive screening for 22q11.2 microdeletion
- Detects triploidy, complete molar pregnancy, and vanishing twin
- Provides highly accurate fetal sex determination
Explore published scientific studies on the Panorama test
Conditions under which the test cannot be performed:
- For IVF patients using a donor egg/surrogacy in combination with a multiple pregnancy;
- Spontaneously conceived pregnancy with an established “vanishing twin” phenomenon (fetal demise), provided that the twins are dizygotic. If the twins are monozygotic and a vanishing twin has been identified, the test can be performed. Note: chorionicity does not determine zygosity.
- The minimum fetal fraction after DNA extraction must be 2.8%
- In multiple pregnancies involving triplets or more.
- In patients with a history of bone marrow or stem cell transplantation.
The test can be performed from 9 weeks of gestation in an ongoing pregnancy. No special preparation is required for the test.
Available testing options:
| Testing Panels | Conditions Screened | Optional | Cost |
|---|---|---|---|
| PANORAMA BASIC PANEL | Down syndrome, Edwards syndrome, Patau syndrome, triploidy | fetal Rh factor determination + fetal sex determination | |
| PANORAMA STANDARD PANEL | Down syndrome, Edwards syndrome, Patau syndrome, Turner syndrome, X & Y chromosome abnormalities; | fetal Rh factor determination + fetal sex determination | |
| PANORAMA STANDARD PANEL + 22q11.2 DELETION | Down syndrome, Edwards syndrome, Patau syndrome, Turner syndrome, X & Y chromosome abnormalities; triploidy; 22q11.2 deletion | fetal Rh factor determination + fetal sex determination | |
| PANORAMA EXTENDED PANEL | Down syndrome, Edwards syndrome, Patau syndrome, Turner syndrome, X & Y chromosome abnormalities; triploidy; 22q11.2 deletion; fetal sex determination; fetal Rh factor determination; PLUS five microdeletion syndromes: 22q11.2 deletion syndrome, Cri-du-chat syndrome (5p-), 1p36 deletion syndrome, Prader-Willi syndrome (15q11-13), Angelman syndrome (15p-) | fetal Rh factor determination + fetal sex determination |
Limitations of the method:
1) Depending on the characteristics of the pregnancy, screening for certain conditions may be subject to limitations. Therefore, consultation with a medical geneticist is required before testing.
2) In rare cases, a sample may not yield a result, and an additional sample may be requested.
3) Potential causes of inaccurate results include:
- Mosaicism
- Low fetal fraction (fetal DNA)
- The test does not detect all possible deletions associated with microdeletion syndromes.
- The test has been validated only for complete deletions of the specified loci and may not detect smaller deletions.
- The microdeletion risk assessment depends on the fetal fraction because deletions involving the maternally inherited chromosome are more difficult to detect when the fetal fraction is low.
- *Fetal Rh factor determination is performed only when the mother is Rh-negative
Important! Test results should always be interpreted by a clinician in the context of the patient’s clinical findings and medical history, with subsequent genetic counseling when appropriate.
Required biological material
- Maternal venous blood